Take care of yourself, of your brain and of your body!
Exercise regularly, have an healthy diet and a well-targeted dietary supplementation in specific vitamins, which help you stay fit and active.
FolPlus® +D3 has been developed to help you stay in shape.
In combination, these three micronutrients regulate homocysteine level in the blood. Homocysteine is a naturally occurring amino acid which is constantly produced as a cytotoxic intermediate by metabolic processes in the organism.
An increased homocysteine plasma level is caused by:
- inadequate B vitamin intake (B6, B9 and B12)
- rare genetic defects, genetic factors and diseases
- physiological factors such as advancing age
- specific lifestyle
If the homocysteine level in the blood is too high, this has a negative effect on fitness and motivation as well as on memory and mental capacity. In addition, the effectiveness of the immune system can be reduced in the longer term. Studies have shown that elevated blood homocysteine levels are associated with cognitive dysfunction and dementia.
With a single tablet of FolPlus® during the day, you can supplement your diet sensibly and specifically with three important micronutrients that support your body in maintaining a regulated homocysteine level and in connection with maintaining mental and physical performance.
Hyperhomocysteinemia means an increase in the level of homocysteine in the blood (above 15 micromoles per litre). High homocysteine levels affect the inner layer of blood vessels, which can lead to an increased risk of atherosclerosis or constriction of the blood vessels. Studies have shown that high homocysteine plasma levels are associated with various age-related pathologies such as osteoporosis, Alzheimer’s disease, Parkinson’s disease, stroke and cardiovascular disease.
Production of homocysteine
Methionine and cysteine are amino acids required for the biosynthesis of proteins. Methionine, an essential amino acid and must be supplied by food. Homocysteine is different from cysteine by an additional methylene group (-CH2-). Homocysteine is biosynthesized from methionine and can either be transformed into methionine (the methionine synthase pathway) or converted to cysteine (the cystathionine pathway or reverse trans-sulfuration). The remethylation to methionine requires folic acid and vitamin B12, the conversion to cysteine requires the action of vitamin B6.
The methionine synthase pathway
This reaction transforms the primary biologically active form of folate (5-methyltetrahydrofolate or 5-MTHF) into tetrahydrofolate (THF – a derivative of folate), while a methyl group is converted into homocysteine to form methionine. This reaction requires cobalamin (vitamin B12).
The folate pathway
5-MTHF functions as a methyl donor for homocysteine remethylation to methionine, which releases a THF and the cycle can begin again.
If there is not enough vitamin B12 available, 5-methyltetrahydrofolate (5-MTHF) cannot be converted into THF due to the “methyl trap”. This affects the folate pathway and leads to an increase in homocysteine, which damages the cells, although there may be enough folate or folic acid available.
The cystathionine pathway
During this reaction, an enzyme catalyzes the transformation of homocysteine into cystathionine using pyridoxine (vitamin B6) as a co-factor. The activity of another enzyme converts from cystathionine to cysteine.
Composition and Instructions
|Vitamin B6||4 mg||280|
|Folic acid B9||400 μg||200|
|Vitamin B12||30 μg||1200|
|Vitamin D3||20 μg (800 IU)||400|
*% of recommended daily allowance in the EU.
Bulking agent: Cellulose, Calcium hydrogen phos phate; Pyridoxine Hydrochloride (vit. B6); coating agent: Hydroxypropyl methylcellulose; anti-caking agent: Magnesium salts of fatty acids; Pteroylmonoglutamic acid (folic acid); Cyanocobalamin (vit. B12); Cholecalciferol (vit. D3)
Free of lactose, fructose, gluten, colorants, flavor and nanoparticles as well as animal constituents.